Buyer's guide · September 2026
Natural Medicines Database (NatMed Pro): comprehensive database subscription cost and access
It costs $182 a year for one clinician, and there is a $69 version most buyers never find.
Every published price, every way into the database without paying, and where the free references genuinely hold up.
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The short answer
What does the Natural Medicines Database cost, and what is it called now?
The Natural Medicines Database is now sold as NatMed Pro by TRC Healthcare, and an individual subscription costs $182 for one year, $327.60 for two and $464.10 for three. It is the same product that launched as the Natural Medicines Comprehensive Database and was later shortened to Natural Medicines, which is why library catalogs and citations still use three different names for one database.
Two things are worth knowing before you pay. TRC also sells NatMed Advisor at $69 a year, which covers the same 1,400 topics as short guides without the commercial products database or the clinical tools. And most people who use this database never buy it personally, because their university or health system library licenses it.
Every published individual price
NatMed Pro and NatMed Advisor rate card
Read from TRC Healthcare's own store in September 2026. The last column is the vendor's own per-month label, and it does not mean what it appears to mean.
| Product | Term | You pay once | Per year | Real per month | TRC's own label | What to know |
|---|---|---|---|---|---|---|
| NatMed Pro | 1 year | $182.00 | $182.00 | $15.17 | $15.17 per month | The standard individual professional subscription. This is the figure almost everyone means by "the Natural Medicines Database subscription". |
| NatMed Pro | 2 years | $327.60 | $163.80 | $13.65 | $27.30 per month | 10% off the two year total. Saves $36.40 against paying yearly. |
| NatMed Pro | 3 years | $464.10 | $154.70 | $12.89 | $38.68 per month | 15% off the three year total. Saves $81.90 against paying yearly. |
| NatMed Advisor | 1 year | $69.00 | $69.00 | $5.75 | $5.75 per month | The lighter sibling: the guides, without the commercial products database or the clinical quick-check tools. |
| NatMed Advisor | 2 years | $124.20 | $62.10 | $5.18 | $10.35 per month | 10% off the two year total. |
| NatMed Advisor | 3 years | $175.95 | $58.65 | $4.89 | $14.66 per month | 15% off the three year total. |
Institutional and group pricing is quoted rather than published. Quoted means TRC prints no figure at all, not that we could not find one.
One database, three names, and a search results page that looks like a market
Search for the Natural Medicines Database and you get library guides from a dozen universities, a vendor site, and pages describing what look like several different products. There is only one. It launched as the Natural Medicines Comprehensive Database, was shortened to Natural Medicines, and now sells as NatMed Pro. Catalogs update at different speeds, so a citation from 2016, a library A to Z list from 2022 and TRC's current store all name the same subscription differently.
That matters practically in two places. When you search your library's database list, try all three names before concluding your institution does not have it. And when you cite a monograph, give the name as it appeared when you retrieved it along with a retrieval date, because the content is revised continuously and a reader following your citation in two years will land on a differently branded page.
The $69 product almost nobody finds
TRC sells two natural medicines products, and the cheaper one is easy to miss because most write-ups of this database do not mention it exists. NatMed Advisor is $69 a year against $182 for NatMed Pro. Both cover the same 1,400 plus topics. The difference is what surrounds the monographs.
NatMed Pro carries the database of more than 300,000 commercial supplement products with ingredients, dosing, third-party certifications and label images, updated daily. It also carries the interactive tools: the interactions checker, effectiveness by condition, nutrient depletions, pregnancy and lactation safety, and the adverse effects search. NatMed Advisor gives you the topics as bite-size guides in English, Spanish and French, and stops there.
The dividing line is honest and easy to apply. If patients hand you specific bottles and you need to say something defensible about that exact product, you need the 300,000 records and you should pay the $182. If your questions are about ingredients in general, or you mostly want something readable to give a patient, Advisor answers them for $113 a year less.
Read the per-month figure carefully
TRC prints a per-month price next to every plan. On the one year plans it is accurate: $182 divided by 12 is the $15.17 shown. On the multi-year plans the same division is applied, so the two year NatMed Pro plan is labeled $27.30 a month even though $327.60 covers 24 months and the real monthly cost is $13.65. The three year plan is labeled $38.68 when the actual figure is $12.89.
The discounts themselves are real, 10% off the total for two years and 15% for three, and the charge is a single payment for the whole term rather than a card billed monthly. Just do the division yourself before you decide the longer term looks expensive, because the label makes the better deal look like the worse one.
When the CME bundle beats buying it standalone
TRC includes NatMed Pro inside the Diamond tier of Prescriber Insights, its CME product, and prices it there as a $182 value. That figure independently confirms the standalone rate, which is a useful cross-check on a page like this. It also creates a real decision for anyone who has to buy CME anyway.
Diamond runs $599 a year for physicians and PAs and $389 a year for APRNs. Note that gap: the same tier of the same product costs $210 less depending on your credential, so check the page for your own license rather than the first one you land on. If you currently spend more than roughly $400 on CME and also want this database, the bundle is worth pricing properly. If you do not need CME, $182 standalone is the cheaper answer and the arithmetic is not close.
Where the free references are genuinely enough
Nobody should pay $182 for something they use four times a year, and the free options in this specific niche are better than the free options for prescription drug information. Memorial Sloan Kettering's About Herbs is maintained by a pharmacist, covers purported uses, adverse effects and interaction notes, and is citable. The NIH Office of Dietary Supplements fact sheets are the better source for vitamins and minerals, not merely an acceptable substitute. NCCIH is good for a fast evidence summary.
What none of them do is the commercial product half. A patient arrives with a bottle containing nine ingredients at unstated doses from a brand you have never heard of, and a free herb reference cannot tell you what is in it, whether the brand has third-party certification, or whether that combination collides with the four drugs on their list. That is the work the $182 buys, and it is the only reason to buy it.
There is also a boundary worth naming. A supplement database answers questions about supplements. Screening a whole medication list for drug-to-drug interactions, contraindications and renal dosing problems is a different job that runs alongside it, and it is the one our drug interaction checker is built for. Clinicians who need both usually end up with both, which is worth budgeting for honestly rather than discovering in month three.
Six ways in, two of them free
How to get Natural Medicines Database access
Check the fourth row before you pay for the first one.
| Access route | Price | Who it suits | Where you sign in | What to know |
|---|---|---|---|---|
| NatMed Pro, bought directly | $182 a year | A pharmacist, dietitian, ND or prescriber who fields supplement questions weekly | trchealthcare.com store, then login.therapeuticresearch.com | Sold as a one-time charge for the whole term rather than a recurring monthly card charge. Two and three year terms cut the annual rate to $163.80 and $154.70. |
| NatMed Advisor, bought directly | $69 a year | Someone who wants reliable answers and patient handouts, not a clinical products database | Same store and sign-in | Covers the same 1,400+ topics in bite-size guides in English, Spanish and French. Drops the 300,000+ commercial product records and the interactive clinical tools. |
| Bundled into Prescriber Insights Diamond | $599 a year (MD, PA), $389 a year (APRN) | A prescriber who has to buy CME anyway | One TRC account covers both | TRC lists NatMed Pro inside the Diamond tier at no extra charge and prices it on that page as a $182 value, which independently confirms the standalone rate. Worth the arithmetic if CME is already in your budget. |
| University or health system library | Quoted, not published | Students, faculty, residents and health system staff | IP recognition or single sign-on through your library | This is how most people who use the database reach it, and it is why so many search results are library guides. Check your library A to Z list before you pay personally. |
| Professional association member rate | Varies, quoted | Members of pharmacy and naturopathic associations | Through the association member portal | TRC runs member landing pages for several associations. There is no published discount schedule, so ask your association directly rather than assuming there is nothing. |
| Free public references | Free | Occasional lookups, patient education, a second opinion | Open web, no account | Memorial Sloan Kettering About Herbs, the NIH Office of Dietary Supplements fact sheets and NCCIH are genuinely good and cost nothing. They do not carry commercial product records or a screening tool. |
What $182 actually buys
Everything inside NatMed Pro
Counts and capabilities as TRC Healthcare states them on its own product page.
1,400+ monographs
Full evidence-based monographs on ingredients and therapies covering use, safety, effectiveness and mechanism. Each one carries printable patient handouts in English, Spanish and French.
300,000+ commercial products
Actual branded supplements with ingredients, dosing, third-party certifications and label images, updated daily. This is the half a free reference cannot replace, because patients arrive holding a specific bottle.
Interactions checker
Screens drugs against natural medicines, including multi-ingredient supplements, and returns evidence-based interaction ratings rather than an undifferentiated warning list.
Effectiveness by condition
Works backwards from a condition or symptom to the natural medicines with evidence behind them, which is the direction the question usually arrives in.
Nutrient depletions
Identifies drug-induced nutrient deficiencies, so you can answer whether a medication is the reason to supplement rather than guessing.
Pregnancy and lactation safety
Consolidated safety information for natural products in pregnancy and breastfeeding, which is otherwise scattered across several sources.
Adverse effects search
Select a symptom and get the natural medicines with evidence suggesting they might cause it. Useful when a patient presents with something unexplained and a supplement drawer.
2025 platform rebuild
TRC rebuilt the site with faster search, full tablet and mobile support, and WCAG 2.1 Level AA conformance. There is no separate native app to buy.
What else you are choosing between
Natural Medicines against the rest of the market
Every figure is that vendor's own published number, read at source in September 2026.
| Product | Vendor | Published price | What it covers | Best for |
|---|---|---|---|---|
| NatMed Pro | TRC Healthcare | $182 a year | Monographs, 300,000+ commercial products, interaction and depletion tools | The clinician who has to give a defensible answer about a specific bottle |
| NatMed Advisor | TRC Healthcare | $69 a year | The same 1,400+ topics as short guides, three languages | Patient education and quick answers without the clinical tooling |
| About Herbs | Memorial Sloan Kettering | Free | Herbs and botanicals, purported uses, adverse effects, interaction notes | Oncology-adjacent questions and anyone who needs a citable free source |
| Office of Dietary Supplements fact sheets | NIH | Free | Vitamins and minerals in depth, professional and consumer versions | Micronutrient questions, where it is genuinely the better source |
| NCCIH herbs at a glance | NIH | Free | Short evidence summaries for common botanicals | A fast sanity check before a longer look |
| UpToDate Lexidrug | Wolters Kluwer | $29.99 a month for one package | Drug monographs with some natural product content | Prescription drug work, with supplements as a secondary concern |
| Micromedex | Merative | Quoted, not published | Tertiary drug information, toxicology, some alternative medicine content | Health systems that already license it |
| epocrates+ | Athenahealth | $179.99 a year, $24.99 a month | Drug monographs, interactions, pill identification | Fast prescription lookups on a phone, not supplement depth |
If you are deciding today
Buying it in the right order
1
Check your library first
If you are affiliated with a university, health system or college of pharmacy, search its A to Z database list for NatMed or Natural Medicines. Institutional access is the single most common route and it costs you nothing.
2
Decide whether you need the products database
The honest dividing line between the $182 and the $69 product is whether patients hand you specific bottles. If they do, you need the 300,000 product records. If your questions are about ingredients in general, Advisor answers them.
3
Do the CME arithmetic before buying standalone
If you already pay for CME, price Prescriber Insights Diamond against your current CME spend plus $182. TRC includes NatMed Pro in that tier, so the comparison sometimes lands in the bundle's favor.
4
Pick the term deliberately
The multi-year discounts are real, 10% and 15% off the total, and the charge is one-time rather than recurring. Ignore the per-month label on the multi-year plans and divide the total by the actual number of months yourself.
Frequently asked
Natural Medicines Database questions, answered
How much is a Natural Medicines Database subscription?
NatMed Pro, the professional Natural Medicines Database, costs $182 for one year for an individual, read at TRC Healthcare's own store in September 2026. Two years is $327.60 and three years is $464.10, which work out to $163.80 and $154.70 a year. It is charged once for the whole term, not monthly.
Is the Natural Medicines Database free?
No. NatMed Pro is a paid subscription starting at $182 a year, and TRC publishes no free tier. Many clinicians reach it at no personal cost through a university or health system library. If you need a genuinely free reference, Memorial Sloan Kettering's About Herbs and the NIH Office of Dietary Supplements fact sheets are open to anyone.
Is NatMed Pro the same as the Natural Medicines Comprehensive Database?
Yes. It is the same product under its third name. It launched as the Natural Medicines Comprehensive Database, was shortened to Natural Medicines, and TRC Healthcare renamed it NatMed Pro. Library guides and citations still use all three names, which is why the search results for this database look like several competing products when there is only one.
What is the difference between NatMed Pro and NatMed Advisor?
NatMed Pro is the clinical database at $182 a year: 1,400+ full monographs, 300,000+ commercial supplement products, and the interaction, nutrient depletion and adverse effect tools. NatMed Advisor is $69 a year and covers the same topics as short guides in English, Spanish and French, without the commercial product records or the clinical tools.
Does the Natural Medicines Database have an interaction checker?
Yes, and it is the main reason clinicians pay for it. The interactions checker screens prescription drugs against natural medicines, handles multi-ingredient supplements rather than single herbs only, and returns graded evidence-based interaction ratings instead of a flat warning. Free herb references generally list interactions in prose without screening a combination for you.
How do I log in to the Natural Medicines Database?
Individual subscribers sign in through TRC Healthcare's account system at login.therapeuticresearch.com, reached from the NatMed Pro site. If your access comes from a university or hospital, do not use that form: start at your library's database list so the link carries your institution's authentication, either IP recognition or single sign-on.
Can I get Natural Medicines Database access through my university library?
Very often, yes. It is a standard health sciences library subscription, which is why library guides from schools across the country dominate the search results for this database. Search your library's A to Z list for NatMed Pro, Natural Medicines or Natural Medicines Comprehensive Database, since catalogs are updated at different times and may list any of the three names.
How do you cite the Natural Medicines Database in APA?
Cite it as an entry in an online reference work: the database name as author and site, the year, the monograph title, and the retrieval URL. Because the product has been renamed twice, name the database as it appears at the time you retrieved the page and give the retrieval date, since monographs are revised continuously and the version you read will not be the version a reader finds later.
Is there a Natural Medicines Database app?
There is no separate paid mobile app to buy. TRC rebuilt the platform in 2025 as a responsive site that works on phones and tablets and meets WCAG 2.1 Level AA, so your subscription covers mobile use through the browser. Older references to a standalone Natural Medicines app describe a version that predates that rebuild.
What is the Sloan Kettering herbal database?
About Herbs, run by Memorial Sloan Kettering's Integrative Medicine Service, is a free public database of herbs, botanicals and supplements maintained by a pharmacist. It covers purported uses, adverse effects and interaction notes, and it is a credible citable source. It does not include commercial product records or a tool that screens a whole medication list.
Is the Natural Medicines Comprehensive Database available as a book or PDF?
Not currently. The Comprehensive Database was published as a printed volume for years, and used copies still circulate, but TRC Healthcare's current store lists only online subscriptions and no print edition. Treat any downloadable PDF of it that you find as an out-of-date copy rather than the live database, because monographs change continuously.
Who actually needs to pay for this database?
The clinicians who get value from it are the ones asked about specific supplement products often enough that free references cost them time: community and clinical pharmacists, dietitians, naturopathic doctors, and prescribers in integrative or functional practice. If you look up a herb a few times a year, the free NIH and Sloan Kettering resources will cover you.
Go deeper
What the rest of the drug information market charges
Pharmacist's Letter cost
The same vendor's CE product, and the $107 tier that is not on the main page.
Facts and Comparisons eAnswers
The comparison reference for pharmacists, and why it no longer stands alone.
Lexidrug subscription plans
What $29.99 a month really buys, and what it leaves out.
Sanford Guide subscription cost
A full published rate card, from a vendor that sells to individuals.
Best drug reference apps
Every published price in the category, side by side.
Polypharmacy review
Screening a long medication list, which is where supplements usually surface.
The half a supplement database does not cover
The supplement is rarely the only thing on the list.
NatMed Pro is the right tool for the bottle in the patient's hand. It still leaves you to work through the eleven prescriptions around it. We run the interaction, contraindication and renal dosing checks across the whole list, then hand you the flags to review and sign off.