Lexicomp drug interaction checker cost, access and the personal Lexidrug app
The Lexicomp drug interaction checker (Lexi-Interact) is not sold on its own: it comes with UpToDate Lexidrug, which costs an individual $29.99 a month on the app after a one month trial. What it screens, the A to X ratings, the three ways in, and what to compare it with.
By the Prescriber.io team
October 2026 · 6 min read
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In short
The Lexicomp drug interaction checker, called Lexi-Interact, is the interactions module of UpToDate Lexidrug and is not sold separately. Individuals get it through the UpToDate Lexidrug app at $29.99 a month after a one month trial; hospitals and schools license it institutionally. It screens drug to drug, drug to allergy and duplicate therapy, including herbals, and rates each pair from A (no known interaction) to X (avoid combination). It does not take the patient's conditions or kidney function into the check.
Most people who search for the Lexicomp drug interaction checker already know it. They used it every day in a hospital, a residency or a pharmacy school, and then the login stopped working: a new job, a graduation, a switch from inpatient to an outpatient practice that does not license Wolters Kluwer content. The tool did not go anywhere. It is still the interactions module inside UpToDate Lexidrug, which is what Lexicomp has been called since Wolters Kluwer folded it under the UpToDate brand. What changed is who pays for it.
Below is what the checker actually screens, the ways to reach it, what a personal subscription costs, and the cheaper or broader options worth comparing before you sign up for a monthly charge.
What the Lexicomp drug interaction checker screens
The checker is called Lexi-Interact. University library guides that document it describe the same scope: drug to drug interactions, drug to allergy interactions and duplicate therapy, with herbal products included alongside prescription and OTC drugs. You build a list, and it returns every pair it knows about with a risk rating and a short monograph covering the mechanism, the evidence and what to do about it.
The risk ratings are the part clinicians remember:
| Rating | Meaning | What you usually do |
|---|---|---|
| A | No known interaction | Nothing |
| B | No action needed | Nothing; the interaction is documented but not clinically meaningful |
| C | Monitor therapy | Prescribe and watch for the effect |
| D | Consider therapy modification | Change the dose, the timing or the drug |
| X | Avoid combination | Pick something else |
Each rating also carries a reliability score for the evidence behind it, which is a big part of why pharmacists trust it over the free consumer checkers. A D with fair evidence and a D with excellent evidence are different conversations with the prescriber.
How to get Lexicomp drug interactions without a hospital login
There are three ways in, and only one of them is a personal purchase.
Through an institution. Hospitals, health systems and schools license Lexidrug Online, and many expose the interactions tool from the UpToDate search page as well, under a Drug Interactions link. Library guides from several universities document exactly that path. If your employer or school has it, this is the cheapest route by a wide margin, because it costs you nothing.
Through the UpToDate Lexidrug app on a personal subscription. On the US App Store the app lists two in-app purchases, Lexicomp Professional Package and Lexi-COMPLETE, each at $29.99 a month, and new users get a one month trial of the Hospital Pharmacist package before the charge starts. The interactions tool is part of the package, alongside the drug monographs, calculators and drug identifier. We break the packages down on the Lexidrug subscription page.
Through a personal UpToDate subscription. UpToDate does not publish a price on any public page, and the store asks for your country, role and a login before it shows one. Whether a given personal plan exposes the Drug Interactions link is something to confirm in the store rather than assume. Our UpToDate subscription cost page walks through that flow, and the UpToDate drug interactions checker page covers the tool itself, its A to X ratings and every way to reach it.
How much does the Lexicomp drug interaction checker cost?
The interaction checker is not sold on its own. You pay for Lexidrug, and the checker comes with it. At $29.99 a month that is about $360 a year if you keep it twelve months, which is the number to compare against everything else on the list. Our Lexicomp subscription cost article tracks the price history and what changed when the app was rebranded.
| Option | What you pay (US) | Interaction scope |
|---|---|---|
| UpToDate Lexidrug app | $29.99 a month, one month trial | Drug, allergy, duplicate therapy, herbals; A to X ratings |
| Micromedex Drug Interactions | No published price, institutional | Drug, herbal, food, ethanol, lab, tobacco, pregnancy, lactation, ingredient duplication |
| Clinical Pharmacology (Elsevier) | $650 a year, individual | Custom interaction reports inside a full drug database |
| epocrates+ | $179.99 a year ($24.99 a month); basic interaction check free | Drug to drug |
| Medscape | Free, ad supported | Drug to drug, OTC, herbals and some foods |
| Prescriber.io | $24 per clinician a month billed annually, $49 monthly | Drug to drug plus conditions, allergies, pregnancy, renal and hepatic function |
If you only want what Lexicomp gives you, the app is the honest answer and $29.99 a month is fair for the depth of the monographs. If you came from a hospital that ran Micromedex instead, our Lexicomp vs Micromedex comparison explains which checker covers what.
Is the Lexicomp interaction checker free?
Not for individuals. There is no free web version for individuals, and the app download needs an active package or the trial before the content opens. The one month trial is the closest thing to free, and it converts to the monthly charge unless you cancel it in your App Store or Google Play subscriptions before it ends. Students and residents almost always have it through their program, so check there first.
What the Lexicomp checker does not see
Lexi-Interact is a list checker. It knows the drugs and the allergies you enter. It does not take the patient's diagnoses, eGFR or liver function as part of the check, so a drug that is contraindicated in heart failure or below a kidney threshold comes back with no flag unless it clashes with another drug on the list. Those answers sit in the individual drug monographs, which means reading each one with the patient in your head.
In a hospital that gap is usually covered by the EHR's own alerts and a pharmacist verifying every order. In a small outpatient practice or a telehealth shift, it often is not. That is the job we built Prescriber.io for: you describe the patient once and one check returns interactions, contraindications, allergy conflicts and renal or hepatic dose adjustments, each with a cited reason. If that is the gap you are trying to close, start with the drug contraindication checker, which shows what a patient-level flag looks like next to a pairwise one.
Who should pay for Lexidrug, and who should not
- Pharmacists who look up monographs all day. Pay for it. The interactions tool is the smaller half of what you are buying; compatibility, dosing tables and the depth of each monograph are the rest.
- Prescribers who mostly need the safety check before signing. You are paying for a full drug encyclopedia to use one tool. A per-clinician check that also covers contraindications and renal dosing may fit better, and costs less on an annual plan.
- Dentists. There is a dental-specific Lexidrug package. Our Epocrates vs Lexicomp comparison covers it for dental prescribing.
- Practices buying for several clinicians. Ask Wolters Kluwer for a group quote rather than stacking personal app subscriptions. A site license is a contract with its own renewal terms, so keep it with the rest of your vendor paperwork in contract management software that tracks renewal dates instead of an inbox thread nobody will find in eleven months.
What to do this week
If you still have institutional access, use it and stop reading. If you lost it, start the Lexidrug trial on the day you can actually test it on real patients, set a reminder for day 25, and compare it during that month with whatever covers the patient-level checks you also need. Prescriber.io is at the top of this page if you want to run the same patient through both and see which flags each one finds.
Frequently asked questions
How much does the Lexicomp drug interaction checker cost?
It comes with UpToDate Lexidrug rather than being sold alone. On the US App Store the Lexicomp Professional Package and Lexi-COMPLETE are each $29.99 a month, after a one month trial for new users. That is about $360 a year if you keep it. Institutional pricing is quoted by Wolters Kluwer.
Is the Lexicomp drug interaction checker free?
Not for individuals. There is no free web version; the app needs an active package or the one month trial. Hospitals, health systems and schools often provide it at no cost to staff and students, so check institutional access before you pay.
What do the Lexicomp interaction risk ratings mean?
A means no known interaction, B no action needed, C monitor therapy, D consider therapy modification and X avoid combination. Each rating comes with a reliability rating for the evidence and a monograph explaining the mechanism and the management.
Can I use Lexicomp drug interactions through UpToDate?
Many institutional UpToDate accounts show a Drug Interactions link on the search page that opens the Lexicomp tool, as several university library guides document. For a personal UpToDate plan, confirm in the store whether the link is included before you buy.
Does Lexicomp check drug-disease interactions?
Lexi-Interact screens drug to drug, drug to allergy and duplicate therapy. Disease and organ function cautions sit in each drug monograph, so you read them drug by drug. A checker that takes the patient description can flag them in the same pass as the interactions.
What is a cheaper alternative to the Lexicomp interaction checker?
Medscape and the basic Epocrates app check drug to drug interactions for free. Prescriber.io costs $24 per clinician a month on an annual plan and adds contraindications, allergies and renal and hepatic dosing to the interaction screen. Clinical Pharmacology is $650 a year for a full drug database.
See Prescriber.io check a prescription
The assistant surfaces interactions and contraindications for review, flags renal and hepatic dose adjustments, and suggests guideline-based alternatives with cited sources. You review, verify and sign every prescription.