Drug handbook buyer's guide
Drug Information Handbook (Lexicomp) price, 33rd edition stock and the Lexidrug app
The 33rd edition lists at $146.93, and in September 2026 it was out of stock at Amazon and gone from the ACCP store. The same Lexicomp content costs $29.99 a month in the Lexidrug app.
Below is where the book can still be bought, what an older edition misses, and which paid reference to take instead.
Press Run check for the interaction, contraindication, dosing and alternatives on this pair.
Not matched, so not checked: .
Nothing on this pair matched a row in the reference tables behind this check. That is not a clearance: it means these references do not name this combination.
Guideline-based alternatives
That was your demo check, run on the same references the desk uses. The desk adds renal dosing against an estimated clearance, hepatic review, unlimited checks, saved history and your sign-off on every card.
The on-page check covers five prescribing scenarios and never invents clinical output, so it will not produce a card for this pair.
The full Prescriber.io desk checks any regimen against interactions, contraindications, and renal or hepatic dosing, with cited sources for you to verify.
Interaction
Contraindication / allergy check
Dosing guidance (renal / hepatic)
Guideline-based alternatives
Decision support. You verify against official sources and sign.
Clinician in the loopDecision support for licensed clinicians. Prescriber.io does not diagnose or prescribe and is not a substitute for professional clinical judgment.
The short answer
How much is the Lexicomp Drug Information Handbook?
The Lexicomp Adult Drug Information Handbook, 33rd edition (June 2024, ISBN 978-1-59195-397-5), lists at $146.93 in the US. In September 2026 Amazon had it out of stock with no restock date, and the ACCP store had removed both the 33rd and 32nd edition listings. The 32nd edition is still listed at $74.96. The same Lexicomp drug content is sold today as the UpToDate Lexidrug app, at $29.99 a month after a one month trial.
Read at Amazon, the ACCP store, a university campus store, HPC International, a European bookseller and the US App Store. No reseller estimates.
Where to buy it
Drug Information Handbook stock, seller by seller
What each seller showed when we checked in September 2026.
Amazon.com
33rd edition
"We don't know when or if this item will be back in stock."
ACCP store
33rd and 32nd
Both listings return "Sorry that product is no longer available."
University campus store
33rd edition
Shows the $146.93 list price and points to an electronic version.
HPC International
32nd edition
The previous edition, October 2023.
European bookseller
33rd edition
€180.48 before shipping to the US.
Lexidrug app
Continuously updated
$29.99 a month after a one month trial.
Why the handbook is hard to buy in 2026
Nobody has published a reason. What the storefronts show is consistent, though: Amazon does not know when the 33rd edition will be back, the ACCP store now answers both the 32nd and 33rd edition pages with "no longer available", and a university bookstore that lists the book cannot supply it. ACCP still sold the Pediatric and Neonatal Dosage Handbook the day before, so this is not the store closing its Lexicomp shelf entirely.
Wolters Kluwer has spent the last few years moving Lexicomp into the UpToDate brand as Lexidrug, and its product pages now lead with the app and database. The handbook is a printed snapshot of that same database. If you need Lexicomp drug information this week, the app is the one format that is reliably in stock.
Every way to pay
Drug Information Handbook price and the formats that replace it
Two editions of the book, the app with the same content, and the nearest print and database routes.
| Format | Price | Term | Built for | What to know |
|---|---|---|---|---|
| Drug Information Handbook, 33rd edition | $146.93 list | Softcover, bought once | Anyone who wants the current print book | June 2024, ISBN 978-1-59195-397-5. Out of stock at Amazon and ACCP, not available at the campus store that lists it. |
| Drug Information Handbook, 32nd edition | $74.96 | Softcover, bought once | Study use, a backup desk copy | October 2023, ISBN 978-1-59195-394-4, from HPC International. One edition behind, so it misses the 27 drugs added in the 33rd. |
| UpToDate Lexidrug app | $29.99 a month | Monthly, after a one month trial | A clinician who wants the same content updated | The trial is the Hospital Pharmacist package. About $360 a year, and it stops the day you cancel. |
| Pediatric and Neonatal Dosage Handbook, 31st edition | $114.95 ($104.95 ACCP members) | Softcover, bought once | Pediatric and NICU work | The companion Lexicomp title for children, still sold by ACCP in September 2026. |
| AHFS Drug Information 2026 | $491 list, $373 members | Softcover, members only | A pharmacist who wants a current print book now | ASHP sells it to members only. The licensed AHFS app is $99.99 a year with no membership. |
| Clinical Pharmacology (Elsevier) | $650 a year | Annual, individual | A consultant or independent pharmacist | Full online drug database with IV compatibility and calculators, not a handbook. |
US prices unless marked, read at each seller in September 2026. The price at checkout is the one that binds.
What the 33rd edition holds
What you are paying for in the Adult Drug Information Handbook
Figures from the 33rd edition product copy.
1,456 drug monographs
Adult drugs in a dictionary-style A to Z, cross-referenced by US brand names and index terms.
Up to 32 fields per drug
Dosing, renal and hepatic adjustments, interactions, adverse reactions and monitoring sit in fixed fields, so you learn where to look.
27 new monographs
Drugs added since the 32nd edition. This is the gap a cheaper older copy leaves open.
35+ pages of appendix
Comparison tables and therapy recommendations, with updated topics on prothrombin complex concentrates, topical corticosteroids and CYP450 inhibitors and inducers.
Pharmacologic category index
Find every drug in a class, useful when you are looking for a substitute rather than a single name.
APhA endorsed
The American Pharmacists Association endorses the handbook, which is why many pharmacy schools still list it.
Book editions vs the live database
Snapshot, $74.96
Snapshot, $146.93 list, out of stock
Live, $29.99 a month
The book is a snapshot, the app is the source
Every edition of the Drug Information Handbook is printed from the Lexicomp database as it stood at press time. The 33rd edition went to press in 2024; anything approved, relabeled or withdrawn since then is not in it, and a 32nd edition is a year further behind.
That is fine for learning drug classes or preparing for an exam. It matters when you are dosing a patient on a newer agent, which is exactly when a pharmacist or prescriber reaches for a handbook. We do not reproduce any monograph content here; it is Wolters Kluwer's licensed data.
Is there a Drug Information Handbook app?
Not under that name. The digital form of the handbook is UpToDate Lexidrug, the app and web database Wolters Kluwer sold as Lexicomp until the rebrand. New users on the US App Store get a one month trial of the Hospital Pharmacist package, and after that it bills $29.99 a month. The in-app options are the Lexicomp Professional Package and Lexi-COMPLETE, both at $29.99.
Two things make the app a better buy than the book for most working clinicians: it updates continuously, and you can stop paying. Five months cost about the same as the $146.93 list price of the book. What it does not give you is a copy you own; cancel and the content goes with it. Our Lexidrug subscription plans guide breaks down what each package holds, and the Lexicomp subscription price guide covers the trial and billing terms.
Should you buy the 32nd edition for $74.96?
For a pharmacy student, a technician studying for certification or anyone who wants a desk reference for drug classes, yes. It is half the 33rd edition's list price and the vast majority of monographs are unchanged between two consecutive editions.
For patient care, pair it with something current. The 33rd edition added 27 new monographs and revised appendix topics such as prothrombin complex concentrate comparisons and CYP450 inhibitors and inducers. Used copies of the 28th to 31st editions sell even cheaper, and they are a false economy for anyone who will act on what they read.
Drug Information Handbook for Dentistry and the other Lexicomp titles
The adult handbook is one title in a family. Lexicomp also publishes a Drug Information Handbook for Dentistry, with dental fields such as local anesthetic and vasoconstrictor precautions and effects on dental treatment, and specialty handbooks for nursing, oncology and psychiatry. For children there is the Pediatric and Neonatal Dosage Handbook, which ACCP still sold at $114.95 in September 2026; our Pediatric and Neonatal Dosage Handbook price guide compares it with Lexidrug and Harriet Lane.
Dentists should buy the dental title or the dental Lexidrug package rather than the adult handbook. The dental drug reference software comparison shows what Lexidrug for Dentistry adds over Epocrates and what each costs.
Which one to buy
Four recommendations, by how you use a drug handbook
The right answer depends on whether you study, dispense or prescribe.
You want the book on your desk
Set a stock alert for the 33rd edition by ISBN 978-1-59195-397-5 and do not pay a reseller premium above the $146.93 list. If you need print this month, the 32nd edition at $74.96 is fine for study and general lookups, but check any drug approved since late 2023 somewhere current.
You look things up at the point of care
Take the Lexidrug app. At $29.99 a month it is the same Lexicomp content, updated continuously, and the first month costs nothing. Five months of it cost about what the print book lists for.
You are a pharmacist who wants print now
AHFS Drug Information 2026 is in print and current, but ASHP sells it to members only, so it is $373 plus dues. Worth it if you want the membership. If not, the $99.99 AHFS app is the cheaper current route.
You work in dentistry or pediatrics
Buy the specialty title, not the adult handbook. Lexicomp publishes a separate Drug Information Handbook for Dentistry and the Pediatric and Neonatal Dosage Handbook, and each covers what the adult book leaves out.
The wider market
Drug Information Handbook vs AHFS, Lexidrug, epocrates and PEPID
Paid drug references a handbook buyer weighs, with the price each one publishes.
| Reference | What it is | Published US price | Updates |
|---|---|---|---|
| Drug Information Handbook (Lexicomp) | Print handbook, 1,456 adult monographs | $146.93 list, out of stock | Once per edition |
| UpToDate Lexidrug | The same Lexicomp content as an app and web database | $29.99 a month | Continuous |
| AHFS Drug Information | Print reference from ASHP | $491 list, $373 members only | Yearly edition |
| epocrates+ | Point-of-care drug app | $179.99 a year | Continuous |
| PEPID Pharmacist Pro with AHFS | Drug app with AHFS content | $254.95 a year | Continuous |
| Clinical Pharmacology | Online drug database | $650 a year | Continuous |
| Prescriber.io | Checks a whole prescription, not a reference | $24 to $37 per clinician a month | Continuous |
The nearest print alternative is AHFS Drug Information, which is current and in stock but sold by ASHP to members only. Among apps, Epocrates vs Lexicomp is the comparison most handbook buyers end up reading, because epocrates+ is the cheapest paid app on the list.
Where a handbook stops and a prescription check starts
A drug handbook answers one drug at a time. The question a prescriber actually faces is whether this drug fits this patient's whole list, kidneys and liver. Prescriber.io works at that point: you enter the prescribing scenario once, and it checks interactions across every medication, flags contraindications and allergy blockers, and surfaces renal and hepatic dose adjustments with cited sources. It costs $24 to $37 per clinician a month, and the clinician reviews every flag and signs.
Before you pay
Four checks before you buy the Drug Information Handbook
The first one stops most people buying a years-old edition by mistake.
Search by ISBN, not by title
Sellers list 20 years of editions under the same name. The 33rd edition is 978-1-59195-397-5; the 32nd is 978-1-59195-394-4. Anything else is older.
Check the edition year against your use
For exam prep an edition behind is usually fine. For dosing a real patient, a book printed in 2023 cannot know about drugs or labeling changes since.
Refuse marketplace prices above list
When a book is out of stock, third-party sellers price the last copies high. Above $146.93, five months of the Lexidrug app is the better buy.
Confirm what the app package includes
The Lexidrug trial is the Hospital Pharmacist package. If you need pediatric, dental or natural products content, check the package contents before the first month renews.
Straight answers
Questions people search about the Drug Information Handbook
How much is the Lexicomp Drug Information Handbook?
The 33rd edition of the Adult Drug Information Handbook lists at $146.93 in the US. In September 2026 it was out of stock at Amazon, marked no longer available at the ACCP store, and not available at the campus bookstore that lists it. The previous 32nd edition was listed at $74.96 by HPC International.
What is the latest edition of the Drug Information Handbook?
The 33rd edition, published in June 2024 under ISBN 978-1-59195-397-5, is the newest one we found in September 2026. It holds 1,456 drug monographs with up to 32 fields each, adds 27 new monographs and updates appendix topics including prothrombin complex concentrates and CYP450 inhibitors and inducers.
Why is the Drug Information Handbook out of stock?
Neither the publisher nor the sellers explain it. What we could see in September 2026 is that Amazon does not know when it will be back, and ACCP has removed both the 32nd and 33rd edition listings. Wolters Kluwer now sells Lexicomp content mainly through the Lexidrug app and database, so print runs may be smaller.
Is there a Drug Information Handbook app?
Not under the handbook's name. The app with the same content is UpToDate Lexidrug, formerly Lexicomp, from Wolters Kluwer. It bills $29.99 a month after a one month trial of the Hospital Pharmacist package and updates continuously, so it never goes out of print the way the book has.
Is the Drug Information Handbook the same as Lexicomp?
It is Lexicomp's flagship print title. Lexicomp, now branded UpToDate Lexidrug by Wolters Kluwer, publishes the handbook from the same drug database it sells as an app. The book is a snapshot of that database at press time; the app is the live version with more fields and more drugs.
Is an older Drug Information Handbook edition good enough?
For studying pharmacology, usually yes. For patient care, treat it as a starting point only. The 33rd edition alone added 27 drugs, and every edition revises doses, warnings and interactions, so check anything you will act on in a current source.
Who publishes the Drug Information Handbook for Dentistry?
Lexicomp publishes it as a separate title, originally edited by Richard L. Wynn, with dental-specific fields such as local anesthetic and vasoconstrictor precautions and effects on dental treatment. Dentists who want the same content digitally usually buy Lexidrug for Dentistry rather than the adult handbook.
What can I buy instead of the Drug Information Handbook?
The closest replacement is the Lexidrug app at $29.99 a month, because it is the same content. In print, AHFS Drug Information 2026 is current at $491 list or $373 for ASHP members. As apps, epocrates+ costs $179.99 a year and PEPID Pharmacist Pro with AHFS $254.95 a year.
Go deeper
Other drug references, priced
Lexidrug subscription plans
What $29.99 a month buys, package by package.
CostAHFS Drug Information price
The in-print alternative, and its $99.99 app.
CostTrissel's Handbook price
The IV compatibility handbook, now sold by ASHP.
CostPediatric Dosage Handbook price
The companion Lexicomp title, $114.95.
CostClinical Pharmacology cost
A full drug database at $650 a year.
ToolDrug interaction checker
Checks the whole medication list at the point of prescribing.
The handbook covers one drug. We check the whole prescription.
Prescriber.io checks interactions, flags contraindications, surfaces renal and hepatic dosing and suggests guideline-based alternatives, with cited sources. You review, verify, and sign.
Decision-support for licensed clinicians. Prescriber.io does not diagnose or prescribe autonomously and is not a substitute for professional clinical judgment. Always verify against official sources. Lexicomp, Lexidrug and UpToDate are trademarks of Wolters Kluwer; AHFS is a trademark of ASHP. Prescriber.io is not affiliated with Wolters Kluwer, ASHP, ACCP, APhA, Epocrates, PEPID or Elsevier.